Friday, March 30, 2012
GenomeRNAi Announces v7.0
The folks at GenomeRNAi just announced release of a version 7.0 of their database, including 28 newly available human cell-based RNAi screen data sets.
Monday, March 26, 2012
Breaking Report: Regulators of Hh Secretion
On my desk to read today? A report on a full-genome screen performed at the DRSC.
The authors include information that might be generally useful to screeners, particularly those performing or currently analyzing the results of luciferase-based assay readouts. The study also includes follow-up using in vivo RNAi.
Aikin et al. (2012) A Genome-Wide RNAi Screen Identifies Regulators of Cholesterol-Modified Hedgehog Secretion in Drosophila. PLoS One. 2012;7(3):e33665. PubMed ID: 22432040
The authors include information that might be generally useful to screeners, particularly those performing or currently analyzing the results of luciferase-based assay readouts. The study also includes follow-up using in vivo RNAi.
Aikin et al. (2012) A Genome-Wide RNAi Screen Identifies Regulators of Cholesterol-Modified Hedgehog Secretion in Drosophila. PLoS One. 2012;7(3):e33665. PubMed ID: 22432040
Tuesday, March 20, 2012
Breaking Report: Proteasome Components & Apical Localization
Also on my desk to read today? A report that includes an in vivo RNAi screen and another that includes screening with deficiencies, classical alleles and in vivo RNAi.
Yano et al. (2012) Identification of proteasome components required for apical localization of Chaoptin using functional genomics. J. Neurogenet. Mar 14. PubMed ID: 22417167
Tan et al. (2012) Genetic screen for regulators of lymph gland homeostasis and hemocyte maturation in Drosophila. G3. 2(3):393-405. PubMed ID: 22413093
Yano et al. (2012) Identification of proteasome components required for apical localization of Chaoptin using functional genomics. J. Neurogenet. Mar 14. PubMed ID: 22417167
Tan et al. (2012) Genetic screen for regulators of lymph gland homeostasis and hemocyte maturation in Drosophila. G3. 2(3):393-405. PubMed ID: 22413093
Upcoming: Special Issue on RNAi in Genes
The journal Genes is planning a special open access issue on RNA interference.
Website: http://www.mdpi.com/si/genes/RNA_interference/
Guest Editor: Prof. Dr. Jeremy C. Simpson
Deadline for manuscript submissions: 15 August 2012
Website: http://www.mdpi.com/si/genes/RNA_interference/
Guest Editor: Prof. Dr. Jeremy C. Simpson
Deadline for manuscript submissions: 15 August 2012
The Structure of Human Dicer
On my desk to read today? A paper that provides insight into Dicer function.
Lau PW, Guiley KZ, De N, Potter CS, Carragher B, Macrae IJ. The molecular architecture of human Dicer. Nat Struct Mol Biol. 2012 Mar 18. PubMed ID: 22426548
Lau PW, Guiley KZ, De N, Potter CS, Carragher B, Macrae IJ. The molecular architecture of human Dicer. Nat Struct Mol Biol. 2012 Mar 18. PubMed ID: 22426548
Tuesday, March 13, 2012
FlyBase Survey
Fly people: Take the FlyBase survey! This is our opportunity to be counted as active FlyBase users and make suggestions they will follow up on in future years!
Friday, March 2, 2012
Breaking Report: Cross-system look at the Beta Catenin destruction complex
On my desk to read today? A study that combines cell-based RNAi and in vivo studies in Drosophila with studies in human cultured cells to look at the beta-Catenin destruction complex.
Roberts et al. (2012) Defining components of the bcatenin destruction complex and exploring its regulation and mechanism of action during development. Open Access in PLoS One.
Roberts et al. (2012) Defining components of the bcatenin destruction complex and exploring its regulation and mechanism of action during development. Open Access in PLoS One.
Subscribe to:
Posts (Atom)
Posts
