On my desk this morning? A review by Flannagan and Grinstein on the use of knockdown approaches in Drosophila and zebrafish to study phagocytosis of bacteria. The original article is Ulvila et al. (2011). Info on both below.
Flannagan & Grinsten (2011) Fly fishing with RNAi catches novel effectors of phagocytosis. J. Leukoc. Biol. 89:643-645.
Ulvila et al. (2011) Cofilin regulator 14-3-3[] is an evolutionarily conserved protein required for phagocytosis and microbial resistance. J. Leukoc. Biol. 89:649-659.
Showing posts with label zebrafish gene knockdown. Show all posts
Showing posts with label zebrafish gene knockdown. Show all posts
Tuesday, August 2, 2011
Thursday, May 20, 2010
Breaking Reports: A small-scale and a genome-wide fly RNAi screen
What's on my desk to read today?
A small, focused Drosophila RNAi screen and another that went genome-wide.
Both papers are related to host cell-pathogen interactions.
Serio et al. (2010) Defining a Core Set of Actin Cytoskeletal Proteins Critical for Actin-Based Motility of Rickettsia. Cell Host Microbe 7(5):388-398.
Valanne et al. (2010) Genome-Wide RNA Interference in Drosophila Cells Identifies G Protein-Coupled Receptor Kinase 2 as a Conserved Regulator of NF-{kappa}B Signaling. J Immunol. 2010 Apr 26. [Epub ahead of print].
Monday, May 3, 2010
Breaking News: NF-kappa-B Genome-wide Drosophila cell RNAi screen
What's on my desk to read today? A report of a genome-wide fly RNAi screen designed to query the NF kappa B pathway. Includes follow-up studies in zebrafish using morpholinos to knock down gene function in that organism.
Valanne et al. (2010) Genome-Wide RNA Interference in Drosophila Cells Identifies G Protein-Coupled Receptor Kinase 2 as a Conserved Regulator of NF-{kappa}B Signaling. J Immunol. 2010 Apr 26. [Epub ahead of print]. PMID: 20421637.
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