Showing posts with label Saleh. Show all posts
Showing posts with label Saleh. Show all posts

Thursday, May 30, 2013

Recent review--RNAi and viral defense

Karlikow M, Goic B, Saleh MC. RNAi and antiviral defense in Drosophila: Setting up a systemic immune response. Dev Comp Immunol. 2013 May 14. PMID: 23684730.

Thursday, March 7, 2013

Fly RNAi pathway and viral defense. Breaking reports.

On my desk to read today? These papers on RNAi as a viral defense.

Sabin LR, Zheng Q, Thekkat P, Yang J, Hannon GJ, Gregory BD, Tudor M, Cherry S. Dicer-2 processes diverse viral RNA species. PLoS One. 2013;8(2):e55458. PMID: 23424633; PMCID: PMC3570552

From the abstract: "This study uncovered several novel, heavily targeted features within viral genomes, offering insight into viral replication, viral immune evasion strategies, and the mechanism of antiviral RNAi."

Goic B, Vodovar N, Mondotte JA, Monot C, Frangeul L, Blanc H, Gausson V, Vera-Otarola J, Cristofari G, Saleh MC. RNA-mediated interference and reverse transcription control the persistence of RNA viruses in the insect model Drosophila. Nat Immunol. 2013 Feb 24. doi: 10.1038/ni.2542. PubMed PMID: 23435119.

From the abstract: "Our results identify a cooperative function for retrotransposons and antiviral RNAi in the control of lethal acute infection for the establishment of viral persistence."

Monday, November 19, 2012

Endogenous targets of RNAi. Breaking report.

Bronkhorst AW, van Cleef KW, Vodovar N, Ince IA, Blanc H, Vlak JM, Saleh MC, van Rij RP. The DNA virus Invertebrate iridescent virus 6 is a target of the Drosophila RNAi machinery. Proc Natl Acad Sci U S A. 2012 Nov 14. PubMed PMID: 23151511.