Monday, November 22, 2010

Ouch! That's hot.

On my desk today? Report of an in vivo screen for genes involved in heat avoidance.

Neely et al. (2010) A genome-wide Drosophila screen for heat nociception identifies alpha-2-delta-3 as an evolutionarily conserved pain gene. Cell 143(4):628-38. PMID: 21074052

Tuesday, November 9, 2010

Breaking Reports: Full-Genome RNAi on cell spreading & a Library Evaluation

On my desk today? Catching up on breaking reports from two different groups--one is a full-genome cell-based RNAi screen and the other a comparative report on genome-wide libraries.

D'Ambrosio & Vale (2010) A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis. J Cell Bio 191(3):471-8. PMID: 21041442.

Horn et al. (2010) Design and evaluation of genome-wide libraries for RNA interference screens. Genome Biol. 11(6):R61. PMID 20550664.