Be Ever-Vigilant!

On my desk to read today?

Sigoillot and King (2011) Vigilance and Validation: Keys to Success in RNAi Screening. ACS Chem Biol. 2011 6(1):47-60.

Breaking Report: Living Cell Microarray Screen

On my desk to read this morning?

Linquist et al. (2011) Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. Genome Research. PMID: 21239477.

False Discovery--Real Publication

Excited to see that a publication from the DRSC is now available online:

Booker et al. (2011) False negative rates in Drosophila cell-based RNAi screens: A case study. BMC Genomicsw 12:50. Open Access.

Breaking Report: Sweet Relief?

Also on my desk today? A report describing the application of RNAi in the field--an effort to address honeybee colony collapse disorder.

Hunter et al. (2010) Large-Scale Field Application of RNAi Technology Reducing Israeli Acute Paralysis Virus Disease in Honey Bees (Apismellifera, Hymenoptera: Apidae). PLoS Pathogens. Open Access.

The authors note that "To our knowledge, this is the first successful large-scale real world use of RNAi for disease control."

Breaking Reports: Screen & Review

On my desk to read, early in this new year? Two papers from our near neighbors in the Perrimon lab.

Neumüller and Perrimon (2010) Where gene discovery turns into systems biology: genome-scale RNAi screens in Drosophila. Wiley Interdiscip Rev Syst Biol Med. 2010 Dec 31.

Kondo and Perrimon (2011) A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. Sci. Signal. Jan 4. Vol. 4, Issue 154, p. rs1. Note: Screen performed at the DRSC.