Arthropod Genomics Symposium--Abstract deadline approaching

The abstract submission deadline for the 7th Annual Arthropod Genomics Symposium is approaching--March 1st is the due-date for posters to be considered for platform presentations. The event itself is scheduled for June 12-15, 2013 at the University of Notre Dame.

Androgen Receptor & Prostate Cancer. From fly RNAi screen to human cell follow-up. Breaking report.

On my desk to read this President's Day? This report of a genome-wide RNAi screen performed with the NYU RNAi Core using the DRSC 2.0 genome-wide library.

Imberg-Kazdan K, Ha S, Greenfield A, Poultney CS, Bonneau R, Logan SK, Garabedian MJ. A genome-wide RNA interference screen identifies new regulators of androgen receptor function in prostate cancer cells. Genome Res. 2013 Feb 12. PubMed PMID: 23403032.

Ranking the Rankings. Breaking report.

On my desk to read today--this report of comparison among large-scale screen ranking methods and development of a new approach.

Siebourg J, Merdes G, Misselwitz B, Hardt WD, Beerenwinkel N. Stability of gene rankings from RNAi screens. Bioinformatics. 28(12):1612-8. PMID: 22513992.

RNAi rescue assay and snRNAs. Breaking report.

Chen J, Waltenspiel B, Warren WD, Wagner EJ. Functional Analysis of the Integrator Subunit 12 Identifies a Microdomain that Mediates Activation of the Drosophila Integrator Complex. J Biol Chem. 2013 Jan 3. PubMed PMID: 23288851.

Image analysis script for stress granules and processing bodies. Breaking report.

These authors describe a script developed to analyze a specific set of phenotypes in high-throughput image-based screens such as RNAi screens.

Perez-Pepe M, Slomiansky V, Loschi M, Luchelli L, Neme M, Thomas MG, Boccaccio GL. BUHO: A MATLAB Script for the Study of Stress Granules and Processing Bodies by High-Throughput Image Analysis. PLoS One. 2012;7(12):e51495. doi: 10.1371/journal.pone.0051495. PMID: 23284702; PMCID: PMC3527446.

RNAi and RNA analysis. Cell cycle study. Breaking report.

These authors follow RNAi screening for DNA content in S2 cells with transcriptional profiling to uncover transcriptional networks. Bonke M, Turunen M, Sokolova M, Vähärautio A, Kivioja T, Taipale M, Björklund M, Taipale J. Transcriptional networks controlling the cell cycle. G3 (Bethesda). 2013 Jan;3(1):75-90. doi: 10.1534/g3.112.004283. PubMed PMID: 23316440.

Targeted in vivo screen for Notch pathway regulators. Breaking report.

Zhang J, Liu M, Su Y, Du J, Zhu AJ. A Targeted In Vivo RNAi Screen Reveals Deubiquitinases as New Regulators of Notch Signaling. G3 (Bethesda). 2012 Dec;2(12):1563-75. doi: 10.1534/g3.112.003780. PMID: 23275879; PMCID: PMC3516478.