Tuesday, January 27, 2009

Integrating Data, Prioritizing Genes


What am I reading today?
  Aerts et al. (2009) Integrating computational biology and forward genetics in Drosophila.  

Free full text from PLos Genetics.  
Associated HighFly database and software tools here.

Why am I reading it? Making the most of existing experimental evidence and computational predictions in planning new experiments, analyzing results, and integrating data sets presents interesting challenges. The authors describe a means of prioritizing genes via integrated data, and the application of the tool to predict--and then directly test using a genetic approach--genes predicted to interact with atonal.

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