A cell-based screen from the Boutros group on innate immunity:
Kuttenkeuler et al. (2010) A large-scale RNAi screen identifies Deaf1 as a regulator of innate immune responses in Drosophila. J Innate Immun. 2010 Feb;2(2):181-94. Epub 2009 Oct 13.
And an in vivo screen from the Penninger group on heart function:
Neely et al. (2010) A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. 2010 Apr 2;141(1):142-53.