On my desk to read today? A paper that describes using in vivo RNAi to sensitize strains, then test potential insecticides for activity that might otherwise be masked by a wild-type organism's ability to detox.
Shah et al. (2011) Insecticide detoxification indicator strains as tools for enhancing chemical discovery screens. Pest Manag Sci. doi: 10.1002/ps.2218. PMID: 21681918.