Breaking Report: RNAi Pathways

On my desk to ready this morning? A new report that suggests the possibility of a Dicer-independent pathway for generation of siRNAs in flies.

Tchurikov & Kretova (2011) Both piRNA and siRNA Pathways Are Silencing Transcripts of the Suffix Element in the Drosophila melanogaster Germline and Somatic Cells. PLoS One. 6(7):e21882. PubMed ID: 21779345

Breaking Report: New Review

On my desk to read this morning? A new review from C. Bakal that includes discussion of complex image-based readouts as well as other topics in fly RNAi screening.

Bakal C. (2011) Drosophila RNAi screening in a postgenomic world. Brief Funct. Genomics. PubMed PMID: 21752787.

Breaking Report: RNAi Pathway & Lysosome-Related Organelles

On my desk to read this morning? A report related to the endogenous biology of the RNAi pathway.

Harris et al. (2011) Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing. J Cell Biol. 194(1):77-87. PMID: 21746852.

Breaking Report: Role for RNAi Pathway in Chromosome Segregation

Also on my desk to read today?

Pek & Kai (2011) DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation. Proc Natl Acad Sci U S A. PMID: 21730191.

Breaking Report: RNAi & Cell Death

On my desk today? A report of a possible link between RNAi pathway activity and cell death.

Xie et al. (2011) Inhibition of RNA Interference and Modulation of Transposable Element Expression by Cell Death in Drosophila. Genetics. PMID: 21596898.

Breaking Report: Chemical Screen in RNAi knockdown background

On my desk to read this morning? A chemical screen in a background sensitized by RNAi. Screened in fly cells with follow-up in a mammalian system.

Gonsalves et al. 2011. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci U S A. 108(15):5954-63. PMID: 21393571; PubMed Central PMCID: PMC3076864.