Breaking Report: Chemical Screen in RNAi knockdown background
On my desk to read this morning? A chemical screen in a background sensitized by RNAi. Screened in fly cells with follow-up in a mammalian system.
Gonsalves et al. 2011. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway.Proc Natl Acad Sci U S A. 108(15):5954-63. PMID: 21393571; PubMed Central PMCID: PMC3076864.
The goals of the FlyRNAi blog are (1) to help biological researchers learn more about RNAi, cell-based assays, Drosophila cell culture, high-throughput screening, fly biology and other related topics, (2) to facilitate conversation about these topics, and (3) to increase visibility of the DRSC. Feedback and questions are welcome.
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