Monday, January 7, 2013

S2 cell and RNAi system for exploring phagocytosis of L. donovani

Peltan A, Briggs L, Matthews G, Sweeney ST, Smith DF. Identification of Drosophila Gene Products Required for Phagocytosis of Leishmania donovani. PLoS One. 2012;7(12):e51831. doi: 10.1371/journal.pone.0051831. PMID: 23272175; PMCID: PMC3521716.

From the abstract:  "Utilising the phagocytic capability of Drosophila S2 cells, together with available tools for modulating gene expression by RNAi, we have developed an experimental system in which to identify host proteins of this type on a genome-wide scale ... These observations suggest that this experimental approach has the potential to identify a large number of host effectors required for efficient parasite uptake and maintenance.

No comments: