Thursday, March 7, 2013

Fly RNAi pathway and viral defense. Breaking reports.

On my desk to read today? These papers on RNAi as a viral defense.

Sabin LR, Zheng Q, Thekkat P, Yang J, Hannon GJ, Gregory BD, Tudor M, Cherry S. Dicer-2 processes diverse viral RNA species. PLoS One. 2013;8(2):e55458. PMID: 23424633; PMCID: PMC3570552

From the abstract: "This study uncovered several novel, heavily targeted features within viral genomes, offering insight into viral replication, viral immune evasion strategies, and the mechanism of antiviral RNAi."

Goic B, Vodovar N, Mondotte JA, Monot C, Frangeul L, Blanc H, Gausson V, Vera-Otarola J, Cristofari G, Saleh MC. RNA-mediated interference and reverse transcription control the persistence of RNA viruses in the insect model Drosophila. Nat Immunol. 2013 Feb 24. doi: 10.1038/ni.2542. PubMed PMID: 23435119.

From the abstract: "Our results identify a cooperative function for retrotransposons and antiviral RNAi in the control of lethal acute infection for the establishment of viral persistence."

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