On my desk to read today? This new report of a Drosophila cell-based RNAi screen for which the researchers used a mechanical assay--shake, swirl, shake--to interrogate cell-cell adhesion.
Toret CP, D'Ambrosio MV, Vale RD, Simon MA, Nelson WJ. A genome-wide screen identifies conserved protein hubs required for cadherin-mediated cell-cell adhesion. J Cell Biol. 2014 Jan 20;204(2):265-79. PMID: 24446484.