In the 'not RNAi (or CRISPR) but might be of interest to blog readers anyway' department:
Sadreyev IR, Ji F, Cohen E, Ruvkun G, Tabach Y. PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles. Nucleic Acids Res. 2015 May 9. pii: gkv452. PMID: 25958392.
From the abstract: "... Analysis of the similarity in patterns of sequence conservation across a
large set of eukaryotes can predict functional associations between
different proteins, identify new pathway members and reveal the function
of previously uncharacterized proteins. We used normalized phylogenetic
profiling to predict protein function and identify new pathway members
and disease genes. The phylogenetic profiles of tens of thousands
conserved proteins in the human, mouse, Caenorhabditis elegans and
Drosophila genomes can be queried on our new web server, PhyloGene. ..."