Galindo KA, Endicott TR, Avirneni-Vadlamudi U, Galindo RL. A rapid one-generation genetic screen in a Drosophila model to capture rhabdomyosarcoma effectors and therapeutic targets. G3 (Bethesda). 2014 Dec 9;5(2):205-17. PMID: 25491943; PMCID: PMC4321029.
From the abstract: "Rhabdomyosarcoma (RMS) is an aggressive childhood malignancy of
neoplastic muscle-lineage precursors that fail to terminally
differentiate into syncytial muscle. The most aggressive form of RMS,
alveolar-RMS, is driven by misexpression of the PAX-FOXO1 oncoprotein ... Here, we report a new approach to dissect RMS,
exploiting a highly efficient Drosophila
PAX7-FOXO1 model uniquely configured to uncover PAX-FOXO1 RMS genetic
effectors in only one generation. ... These studies show the utility of the PAX-FOXO1 Drosophila system as a robust one-generation (F1) RMS gene discovery platform and demonstrate how Drosophila transgenic conditional expression models can be configured for the rapid dissection of human disease. "
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