Tuesday, November 24, 2015

RNAi-based screen for interaction with chd1

Sharon Kim, Lakshmi Bugga, Eugenie S. Hong, Rebecca Zabinsky, Rebecca G. Edwards, Parimal A. Deodhar and Jennifer A. Armstrong. An RNAi-Based Candidate Screen for Modifiers of the CHD1 Chromatin Remodeler and Assembly Factor in Drosophila melanogaster.
Early online at G3.

From the abstract: "... CHD1 ... is present at active genes where it participates in histone turnover and recycling during transcription. ... We found that over-expression of the CHD1 results in defects in wing development and utilized this fully penetrant and reliable phenotype to conduct a small-scale RNAi-based candidate screen to identify genes that functionally interact with chd1 in vivo. ..."

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