Wang Z, Wu D, Liu Y, Xia X, Gong W, Qiu Y, Yang J, Zheng Y, Li J, Wang YF, Xiang Y, Hu Y, Zhou X. Drosophila Dicer-2 has an RNA interference-independent function that modulates Toll immune signaling. Sci Adv. 2015 Oct 16;1(9):e1500228. PMID: 26601278; PMCID: PMC4646792.
From the abstract: "Dicer-2 is the central player for small interfering RNA biogenesis in the Drosophila
RNA interference (RNAi) pathway. Intriguingly, we found that Dicer-2
has an unconventional RNAi-independent function that positively
modulates Toll immune signaling ... The
loss of Dicer-2 expression makes fruit flies more susceptible to fungal
infection. We further revealed that Dicer-2 posttranscriptionally
modulates Toll signaling because Dicer-2 is required for the proper
expression of Toll protein ... Dicer-2 directly binds to the 3' untranslated region (3'UTR) of Toll mRNA via its PAZ (Piwi/Argonaute/Zwille) domain and is required for protein translation mediated by Toll 3'UTR. ... our
indicate an unexpected intersection of the RNAi pathway and the Toll
pathway, and provide new insights into Toll immune signaling, Drosophila Dicer-2, and probably Dicer and Dicer-related proteins in other organisms."