Monday, December 11, 2017

RNAi and the sterile insect technique

Darrington M, Dalmay T, Morrison NI, Chapman T. Implementing the sterile insect technique with RNA interference - a review. Entomol Exp Appl. 2017 Sep;164(3):155-175. PMID: 29200471; PMCID: PMC5697603.

From the abstract: "We review RNA interference (RNAi) of insect pests and its potential for implementing sterile insect technique (SIT)-related control. The molecular mechanisms that support RNAi in pest species are reviewed in detail, drawing on literature from a range of species including Drosophila melanogaster Meigen and Homo sapiens L. ... RNAi represents a plausible, non-GM system for targeting populations of insects for control purposes, if RNAi effector molecules can be delivered environmentally (eRNAi). We consider studies of eRNAi from across several insect orders and review to what extent taxonomy, genetics, and differing methods of double-stranded (ds) RNA synthesis and delivery can influence the efficiency of gene knockdown. ..."

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