GenomeRNAi Update. Breaking Report.

On my desk to read today? This open access update on the DKFZ's GenomeRNAi database of mammalian and Drosophila RNAi screen data.

Schmidt EE, Pelz O, Buhlmann S, Kerr G, Horn T, Boutros M. GenomeRNAi: a database for cell-based and in vivo RNAi phenotypes, 2013 update. Nucleic Acids Res. 2012 Nov 27. PubMed PMID: 23193271.

GenomeRNAi Announces v7.0

The folks at GenomeRNAi just announced release of a version 7.0 of their database, including 28 newly available human cell-based RNAi screen data sets.

New version of Genome RNAi

The Boutros group has launched a version 6 of GenomeRNAi. According to their announcement, the database now contains data from about 100 human cell-based RNAi screens, about 100 fly cell-based RNAi screens (including DRSC screen data), and about 50 in vivo fly RNAi screens. They also now offer the option to input your own data. Check it out!

Breaking Reports

On my desk to read today? Two reports related to fly RNAi studies from the Boutros group and collaborators, describing a computational approach for use with double-knockdown data and a species-spanning study related to TOR pathway signaing.

Axelsson et al. (2011) Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi. BMC Bioinformatics. 12(1):342. PMID: 21849035.

Zacharogianni et al. (2011) ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association. EMBO J. doi: 10.1038/emboj.2011.253. PMID: 21847093.

Breaking Report: ER Proteins

Also on my desk?

Kondylis et al. (2011) Identification of ER proteins involved in the functional organisation of the early secretory pathway in Drosophila cells by a targeted RNAi screen. Open Access at PLoS One.