The Structure of Human Dicer

On my desk to read today? A paper that provides insight into Dicer function.

Lau PW, Guiley KZ, De N, Potter CS, Carragher B, Macrae IJ. The molecular architecture of human Dicer. Nat Struct Mol Biol. 2012 Mar 18. PubMed ID: 22426548

FlyBase Survey

Fly people: Take the FlyBase survey! This is our opportunity to be counted as active FlyBase users and make suggestions they will follow up on in future years!

Breaking Report: Cross-system look at the Beta Catenin destruction complex

On my desk to read today? A study that combines cell-based RNAi and in vivo studies in Drosophila with studies in human cultured cells to look at the beta-Catenin destruction complex.

Roberts et al. (2012) Defining components of the bcatenin destruction complex and exploring its regulation and mechanism of action during development. Open Access in PLoS One.

Local? Assay Technology Seminar

If you are local to HMS you might want to check out the assay technology series seminar hosted by the ICCB-Longwood on Wed. Feb. 1. Details online.

New version of Genome RNAi

The Boutros group has launched a version 6 of GenomeRNAi. According to their announcement, the database now contains data from about 100 human cell-based RNAi screens, about 100 fly cell-based RNAi screens (including DRSC screen data), and about 50 in vivo fly RNAi screens. They also now offer the option to input your own data. Check it out!

Breaking Report: Moesin Dephosphorylation

On my desk to read today? A report of an RNAi screen focused on phosphatases.

Kunda et al. 2012 PP1-Mediated Moesin Dephosphorylation Couples Polar Relaxation to Mitotic Exit. Curr Biol. ePubed 2011 Dec 28. PubMed ID: 22209527

DIOPT & DIOPT-DIST Updated

We recently updated the underlying data sets in DIOPT and DIOPT-DIST. There will be some new relationships (for example, new human gene-fly gene relationships). So if you've searched before it's worth repeating the search. For details feel free to contact the DRSC bioinformatics staff.