The authors conclude in their review of the work that:
The analysis of multiple mutants and multiply perturbed cells provides crucial information for reconstructing the ‘wiring diagram’ of the cell.
Quote from: Giaever & Nislow (2009) Knocking sense into regulatory pathways. Nature Biotechnology 27(2):149-150.
Papers discussed in this News & Views:
Bakal, C. et al. (2008) Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Science 322, 453–456. Featuring work performed at the DRSC.
Capaldi, A.P. et al. (2008) Structure and function of a transcriptional network activated by the MAPK Hog1. Nat. Genet. 40, 1300–1306.