Quote of the Week--Looking Forward

Today's quote comes from a recent News & Views on two papers that describe multiple, simultaneous disruption of gene functions. We here at the DRSC are seeing an increase in the number of studies that combine multiple high-throughput approaches and/or disruption under multiple contexts, working towards understanding networks at a systems level.

The authors conclude in their review of the work that:

The analysis of multiple mutants and multiply perturbed cells provides crucial information for reconstructing the ‘wiring diagram’ of the cell.

Quote from:  Giaever & Nislow (2009) Knocking sense into regulatory pathways. Nature Biotechnology 27(2):149-150.

Papers discussed in this News & Views:

Bakal, C. et al.  (2008) Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Science 322, 453–456.  Featuring work performed at the DRSC.

Capaldi, A.P. et al. (2008) Structure and function of a transcriptional network activated by the MAPK Hog1. Nat. Genet. 40, 1300–1306.