Repeat, Repeat, Repeat

What's on my desk today? A report with advice on the number of replicates necessary to limit false negative and false positive results in RNAi screens--in terms of both the number of negative control wells on each plate and the total number of replicate assay plates to test in primary and secondary screening.

X.D. Zhang & J.F. Heyse (2009) Determination of sample size in genome-scale RNAi screens. Bioinformatics. 25(7):841-844.

First impressions? Their conclusions lead to advice that seems sound, practical and achievable, with different numbers of replicates suggested depending on the experimental goals.