Tuesday, October 15, 2013

Validation with RNAi in study of the Hippo pathway interactome. Recent report.

Kwon Y, Vinayagam A, Sun X, Dephoure N, Gygi SP, Hong P, Perrimon N. The Hippo Signaling Pathway Interactome. Science. 2013 Oct 10. PMID: 24114784.

From the abstract: "... a high-confidence Drosophila Hippo protein-protein interaction network (Hippo-PPIN) consisting of 153 proteins and 204 interactions. Depletion of 67% of the proteins by RNAi regulated the transcriptional coactivator Yorkie (Yki) either positively or negatively."

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