Sailem H, Bousgouni V, Cooper S, Bakal C. Cross-talk between Rho and Rac GTPases drives deterministic exploration of cellular shape space and morphological heterogeneity. Open Biol. 2014 Jan 22;4:130132. PMID: 24451547; PubMed Central PMCID: PMC3909273.
From the abstract: "... We first exploit the shape diversity generated by systematic RNAi screening and comprehensively define the shape space a migratory cell explores. ... We validate the predictions made by our model using live-cell imaging. Our work explains how cross-talk between Rho and Rac can generate different cell shapes, and thus morphological heterogeneity, in genetically identical populations."