Tuesday, November 11, 2014

in vivo genome-wide RNAi screen--regulation of synapse function

Dani N, Zhu H, Broadie K. Two protein N-acetylgalactosaminyl transferases regulate synaptic plasticity by activity-dependent regulation of integrin signaling. J Neurosci. 2014 Sep 24;34(39):13047-65. PMID: 25253852; PMCID: PMC4172800.

From the abstract: "Using a Drosophila whole-genome transgenic RNAi screen for glycogenes regulating synapse function, we have identified two protein ╬▒-N-acetylgalactosaminyltransferases (pgant3 and pgant35A) that regulate synaptic O-linked glycosylation (GalNAc╬▒1-O-S/T). Loss of either pgant alone elevates presynaptic/postsynaptic molecular assembly and evoked neurotransmission strength, but synapses appear restored to normal in double mutants. ..."

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