Monday, February 23, 2015

Review of model organism RNAi screen contributions to understanding host-pathogen interactions

Abnave P, Conti F, Torre C, Ghigo E. What RNAi screens in model organisms revealed about microbicidal response in mammals? Front Cell Infect Microbiol. 2015 Jan 12;4:184. PMID: 25629007; PMCID: PMC4290690.

From the abstract: "The strategies evolved by pathogens to infect hosts and the mechanisms used by the host to eliminate intruders are highly complex. ... The aim of this mini-review is to highlight and describe recent breakthroughs in the field of host-pathogen interactions using RNAi screens of model organisms. We will focus specifically on the model organisms Drosophila melanogaster, Caenorhabditis elegans, and Danio rerio. Moreover, a recent study examining the immune system of planarian will be discussed."

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